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520tph轮胎式移动破碎站-红星机器
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TPH2：揭开药物靶点与生物标志物的神秘面纱 (G121278) BDE-Bio
TPH2，全称为Tumor suppressor protein 2，是一种在多种肿瘤中表达量较高的蛋白质。近/来，科学家们对TPH2的关注逐渐增加，主要原因在于它作为潜在的药物靶点，以及作为肿瘤诊断和监测的生物标志物。本文将从TPH2的生物学功能、药物靶点以及生物标志物三个方面，揭开TPH2的神秘面纱。
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Advances in Tryptophan Hydroxylase-2 Gene Expression
2) 2051A>C interacts with rhTPH2 5′-FR-1485(AT)n and early-life experience to affect the stress response . Besides the 2051A>C, a number of polymorphisms in the rhTPH2 promoter (i.e. 5′-flanking region, 5′-FR) also affect gene expression and may thus affect 5-HT synthesis and the stress response (Chen et al., 2010b). In addition, it has ...
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Frontiers Two eARCHT3.0 Lines for Optogenetic Silencing of ...
2019/1/31 Signals were low-pass filtered at 2 kHz and sampled at 10–20 kHz with a Digidata 1440A (Molecular Devices, San Jose, CA, USA), and data were stored on a computer for subsequent off-line analysis. Cells in which the series resistance (Rs, typically 8–12 MΩ) changed by >20% were excluded for data analysis. In addition, cells with Rs
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A functional alternative splicing mutation in human tryptophan
2010/9/21 A functional alternative splicing mutation in human tryptophan hydroxylase-2. X Zhang 1,2,3, P J Nicholls 2, G Laje 4, T D Sotnikova 1,5, R R Gainetdinov 1,5, P R Albert 6, G Rajkowska 7, C A ...
获取价格Embracing diversity in the 5-HT neuronal system - Nature
2019/4/4 The ability to synthesize and release the neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) 1,2,3,4,5 is a property shared by less than 0.1% of neurons in the mammalian brain — a total of ...
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TPH2 和 TPH1 在生物合成途径中的相互作用。,The FASEB Journal
2022/5/1 色氨酸羟化酶 2 (tph2) 主要位于中缝核的神经元中。一小部分 tph2 也可以通过消化道壁的神经元找到。色氨酸羟化酶-1 (tph1) 主要存在于胰腺中。这种蛋白质的 α 折叠结构决定了血清素通过生物合成途径出现的速度。血清素 (5-ht) 是调节神经心理过程和神经活动受体的关键神经递质。
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血清素能神经传递操纵以了解大脑发育和功能：从 Tph2 遗传模型
5-羟色胺（5-hydroxytriptamine; 5-HT）是一种迷人的神经递质，由于广泛的轴突网络在整个中枢神经系统（CNS）中释放，并在调节无数的生理，行为和认知过程中发挥作用。此外，越来越多的证据表明5-HT神经传递的改变与精神疾病和神经发育障碍（例如抑郁症，自闭症和精神分裂症）的发作有关。
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Tryptophan Hydroxylase 2 - an overview ScienceDirect Topics
Clinical Challenges to Ventilatory Control. David S. Paterson, in Respiratory Physiology Neurobiology, 2013 4.2 Tryptophan hydroxylase 2 (TPH2). Tryptophan hydroxylase is the rate-limiting enzyme for the biosynthesis of 5-HT (Walther et al., 2003).Two isoforms of TPH exist: TPH1, which is responsible for 5-HT synthesis in peripheral tissues, and
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Distribution of two isoforms of tryptophan hydroxylase in
2021/7/2 Serotonin (5-HT) is one of the principal neurotransmitters in the nervous system of vertebrates. It is initially synthesized by hydroxylation of tryptophan (Trp) by means of tryptophan hydroxylase or TPH which is the rate-limiting enzyme in the production of 5-HT. In most vertebrates, there are two isoforms of TPH present, TPH1 and TPH2,
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Functional characterization of the human TPH2 5 ... - Springer
2007/10/31 Tryptophan hydroxylase-2 (TPH2) is a recently identified TPH isoform responsible for neuronal serotonin (5-HT) synthesis, and TPH2 polymorphisms are associated with a range of behavioral traits and psychiatric disorders. This study characterized cis-acting elements and three common polymorphisms (−703G/T,
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Serotonin deficiency induced after brain maturation rescues ...
2021/3/8 Efficiency of induced Tph2 inactivation. The half-life of Tph2 is approximately 2.5 days 37.Thus, we first evaluated the time required after induced Tph2 recombination to reduce the amount of Tph2 ...
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Functional Domains of Human Tryptophan Hydroxylase 2 (hTPH2)*
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin biosynthesis. A novel gene, termed TPH2, has recently been described. This gene is preferentially expressed in the central nervous system, while the original TPH1 is the peripheral gene. We have expressed human tryptophan hydroxylase 2 (hTPH2) and two deletion mutants
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Functional characterization of the human TPH2 5 ... - Springer
2007/10/31 Tryptophan hydroxylase-2 (TPH2) is a recently identified TPH isoform responsible for neuronal serotonin (5-HT) synthesis, and TPH2 polymorphisms are associated with a range of behavioral traits and psychiatric disorders. This study characterized cis-acting elements and three common polymorphisms (−703G/T,
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Serotonin deficiency induced after brain maturation
2021/3/8 Efficiency of induced Tph2 inactivation. The half-life of Tph2 is approximately 2.5 days 37.Thus, we first evaluated the time required after induced Tph2 recombination to reduce the amount of Tph2 ...
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Functional Domains of Human Tryptophan Hydroxylase 2 (hTPH2)*
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin biosynthesis. A novel gene, termed TPH2, has recently been described. This gene is preferentially expressed in the central nervous system, while the original TPH1 is the peripheral gene. We have expressed human tryptophan hydroxylase 2 (hTPH2) and two deletion mutants
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获取价格Anti-TPH2 Antibodies Invitrogen
ADHD7; AU043594; MGC119994; Neuronal tryptophan hydroxylase; NTPH; Tph2; TPRH; TRPH; Tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2; tryptophan hydroxylase 2. 查看更多 收起 Target Video. 6320275314112. TPH2 antibodies from Thermo Fisher Scientific ...
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Brain-specific tryptophan hydroxylase 2 - Oxford Academic
2007/9/27 The odds ratio for the minor allele in the pooled sample was 1.5 (95% CI 1.2–1.9) for rs11178997 (in the 5′-associated haplotype block) and 4.8 (95% CI 1.6–14.8) for rs17110563 encoding the Pro206Ser substitution. Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of ...
获取价格TPH2抗体 [N3C3] (GTX101962) GeneTex中文官方网站
tryptophan hydroxylase 2 , ADHD7 , NTPH 功能与背景 This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases ...
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TPH2: A Key Gene Risk Factor and Potential Therapy Target in
Fig 2. 5-HT signaling, uptake and degradation [31]. 5-HT is stored in vesicles of presynaptic 5-HT neuron, and released after activation, and combine with 5-HT receptor on postsynaptic 5-HT neuron membrane to propagate signaling. 5-HT will be reuptaked back into 5-HT neurons by SERT, or into non-serotonergic cells/neurons by uptake 2 transporter.
获取价格新型药物靶点——外周5-羟色胺 - 雪球
2018/7/24 2.2 胃肠道疾病. 在外周系统中，5-ht类在目唯一的临床应用就是胃肠疾病。5-ht3拮抗剂作为抗吐药，可以治疗肠易激综合(ibs)。肠道及其ecs几乎表达体内所有的tph 1，是体内5-ht的最重要来源，肠道中的5-ht合成被认为是胃肠疾病如ibs的重要靶点。
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TPH2基因敲除小鼠动摇抑郁症根基 ——5-HT与抑郁相关性遭强力
2014/8/4 在这种情况下，Kuhn及其团队开展了本项研究，旨在探讨5-HT在抑郁中所起的作用。色氨酸羟化酶-2（TPH2）是中枢神经系统合成5-HT的初始及限 速酶，该酶催化活性的缺失将导致5-HT合成及释放的减少，而缺乏该酶的小鼠脑内理论上则无该递质存在。
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TPH2 Polyclonal Antibody (PA5-27584) - 赛默飞世尔科技公司
Invitrogen Anti-TPH2 Polyclonal, Catalog # PA5-27584. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody reacts with Human, Mouse, Rat samples. Supplied as 100 µL purified antibody (1.3 mg/mL).
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The response of CD27
2024/2/29 Introduction. Hypersensitivity immune responses to allergens and other environmental factors, including helper T cell cytokine responses and the production of mmunoglobulin E (IgE) antibodies, are key immunologic features of allergic diseases [].Memory B cells, plasmablasts and antibody-producing cells arise during adaptive
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